2 research outputs found
Digital light processing stereolithography of hydroxyapatite scaffolds with bone-like architecture, permeability, and mechanical properties
AbstractThis work deals with the additive manufacturing and characterization of hydroxyapatite scaffolds mimicking the trabecular architecture of cancellous bone. A novel approach was proposed relying on stereolithographic technology, which builds foamâlike ceramic scaffolds by using threeâdimensional (3D) microâtomographic reconstructions of polymeric sponges as virtual templates for the manufacturing process. The layerâbyâlayer fabrication process involves the selective polymerization of a photocurable resin in which hydroxyapatite particles are homogeneously dispersed. Irradiation is performed by a dynamic mask that projects blue light onto the slurry. After sintering, highlyâporous hydroxyapatite scaffolds (total porosity ~0.80, pore size 100â800 ”m) replicating the 3D openâcell architecture of the polymeric template as well as spongy bone were obtained. Intrinsic permeability of scaffolds was determined by measuring laminar airflow alternating pressure wave drops and was found to be within 0.75â1.74 Ă 10â9 m2, which is comparable to the range of human cancellous bone. Compressive tests were also carried out in order to determine the strength (~1.60 MPa), elastic modulus (~513 MPa) and Weibull modulus (m = 2.2) of the scaffolds. Overall, the fabrication strategy used to print hydroxyapatite scaffolds (tomographic imaging combined with digital mirror device [DMD]âbased stereolithography) shows great promise for the development of porous bioceramics with boneâlike architecture and mass transport properties
The chronic use of multiple photosensitizing drugs is associated with Breslow thickness in female melanoma patients: A bicentric retrospective study
We conduct a bicentric cohort study to assess the existence of a possible association between drug-induced photosensitivity and Breslow thickness among melanoma patients. Our study suggests that women who have multiple chronic photosensitizing drugs intake are more likely to develop thicker cutaneous melanoma. Larger cohort studies are needed to confirm this findin